Drug-induced liver injury (DILI) is a harmful reaction to medications, herbs, and dietary supplements that results in liver dysfunction. Based on the distinct clinical patterns of liver damage, DILI ...

Liver tests should be obtained in all patients with suspected DILI. Calculating the ratio of the alanine aminotransferase (ALT) value/ALT upper limit of normal (ULN) divided by the alkaline ...

Chronic cholestasis, defined as the impairment of bile acid formation and/or flow persisting for more than six months, encompasses a broad spectrum of hepatobiliary disorders, both heritable and ...

Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats. These molecules undergo further modification in ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary supplements. It can manifest in different forms, including hepatocellular, ...

An at-home liver test can check for liver disease or help monitor an ongoing condition by measuring certain proteins, enzymes, and bilirubin in your blood. Taking this test can help shed light on the ...

With smart DMPK strategies, cross-domain collaboration, and strong CDMO support, companies are pushing past the challenges of ...

ProQR Therapeutics announces a Phase 1 trial of AX-0810 to evaluate safety and target engagement in cholestatic liver disease. The initiation of the Phase 1 clinical trial for AX-0810 is contingent ...