A new study delving into the genetic drivers of a rare and aggressive childhood cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST) has revealed metabolic frailties in the cancer cells that ...

As humans age beyond early adulthood, their physical and mental functions tend to slowly worsen over time. One of the most common sources of severe mental decline in older adults are neurodegenerative ...

Researchers have discovered that activating the pentose phosphate pathway makes antitumor CD8+ T cells more likely to stay in an immature, stem-like, “precursor” state. Combining this metabolic ...

In a new study published in Nature Metabolism titled “Neuronal Glycogen Breakdown Mitigates Tauopathy via Pentose Phosphate Pathway-Mediated Oxidative Stress Reduction,” researchers from the Buck ...

(a) Proposed protometabolic pentose pathway leading to the accumulation of aldonates followed by nonselective oxidation to uronates, carbonyl migration, and β-decarboxylation. (b) First few steps of ...

Kyoto, Japan -- On good days, the immune system can effectively handle pathogens that invade the body. However, when foreign matter takes the upper hand, the body builds a wall of immune cells called ...