AbstractWhen populations experience suboptimal conditions, the mechanisms involved in the regulation of phenotypic variation can be challenged, resulting in increased phenotypic variance. This kind of ...

Phenotypic screening is a drug discovery approach that identifies bioactive compounds based on their ability to alter a cell or organism’s phenotype (observable characteristics) in a desired manner.

In the early days of pharmaceutical research, discoveries were often made by chance. Take for example the discovery of penicillin by Fleming in the 1930s. Fleming observed that a certain mold stopped ...

The ability to make induced pluripotent stem cells (iPSCs) from adult human somatic cells and use those iPSCs to produce any cell type in the human body opens new avenues for drug discovery. Human ...