For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Over the past few decades, advances in hematology have illuminated how a delicate balance between stem cell self-renewal and ...

Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection ...

The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation - the process ...

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During ...

The use of induced pluripotent stem cells (iPSCs) has led to a paradigm shift in cellular immunotherapy. By reprogramming somatic cells into a pluripotent state, iPSCs represent a renewable source of ...

Glucose is life's main energy source. But a new study reveals a surprising role as a master manipulator of tissue maturation, hinting at its importance in diabetes and cancer. The sugar glucose, which ...

The production of cultured meat depends on the isolation, expansion, and differentiation of animal stem cells into edible tissues. Muscle stem cells, or satellite cells, are central to this process ...

Myelodysplastic syndrome (MDS) arises from defective blood stem cells that progressively lose their normal functions. Japanese researchers have revealed how changes in chromatin accessibility—how DNA ...