Learn about HRSA's Office of Pharmacy Affairs (OPA), ensuring affordable medications through the 340B Drug Pricing Program.

The 340B Rebate Model Pilot Program consists of a selected group of drugs of manufacturers who have submitted plans meeting specific criteria that HRSA has approved.

Discover eligibility and registration details for HRSA's 340B Drug Pricing Program to help entities access discounted medications

Our website provides resources to help 340B Program stakeholders with navigating the 340B Program, including registration and implementation, requirements compliance, program integrity, and more:

To purchase drugs at the 340B price, covered entities must continue to meet the requirements of the 340B Drug Pricing Program.

Which manufacturers and drugs are subject to 340B pricing, and can participating manufacturers offer only a subset of the drugs they manufacture at 340B prices?

The 340B registration and pricing databases are known as the 340B Office of Pharmacy Affairs Information System (340B OPAIS). Authorized users of 340B OPAIS must have a user account with …

The 340B OPAIS pricing module is the sole official federal source for 340B ceiling prices; it calculates those prices based on information supplied by pharmaceutical manufacturers, the Centers for …

A contract pharmacy must register for the 340B Program and ensure compliance with all 340B Program requirements before giving out 340B drugs for a covered entity.

Jul 31, 2025 · Today, the Health Resources and Services Administration (HRSA) announced the availability of a voluntary 340B Rebate Model Pilot Program for drugs on the CMS Medicare Drug …