Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.

CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production.

Nov 13, 2025 · CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Extracutaneous Mastocytoma. Among its related …

Jun 9, 2020 · The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells.

Jan 4, 2025 · These results reveal an unexpected redundancy in the human NK cell response to human cytomegalovirus and suggest that CD2 provides "signal 2" in antibody-driven adaptive …

Jul 25, 2025 · CD2 is a protein found on the surface of certain immune cells, acting as a marker. These specialized proteins play a part in how cells interact and respond within the immune …

Feb 9, 2025 · CD2 is a cell surface glycoprotein expressed on T cells and natural killer (NK) cells, playing a crucial role in cell adhesion, immune synapse formation, and signal transduction. It …

Jul 4, 2025 · The ectopic expression of CD2, which sustains elevated CD2 levels, was shown to optimize CAR-IS, alleviate T-cell exhaustion, and augment the antitumor potential of CAR-T cells.

CD2 is a type I single-pass transmembrane glycoprotein of around 50–58 kDa which is a member of the immunoglobulin superfamily. The protein structure of CD2 underlies many of its …

Explore the CD2 gene, its function, expression, and role in immune responses. Learn about CD2 signaling, deficiency, and its potential implications in various diseases.