Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · snRNA-Seq of 600,000 astrocytes defined seven gene-expression profiles. With worsening Alzheimer’s pathology, homeostatic astrocytes dwindled, while three reactive …
Stunning Detail: Single-Cell Studies Chart Genomic ... - ALZFORUM
Oct 7, 2023 · Integrating snRNA-Seq and snATAC-Seq yields maps of epigenetic regulation within specific cell types (top). Aligning those maps with GWAS variants reveals how the latter …
Transcriptomics Confirm Vascular Changes in Alzheimer’s Brain
Jun 22, 2023 · SnRNA-Seq identifies 11 subtypes of neurovascular cells. In people with Alzheimer’s disease, 2,700 genes dysregulated. Of these, 125 are known to carry AD risk …
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · What spared their memories? To address this, the researchers turned to the larger ROS-MAP cohort, which includes snRNA-Seq data from a single region, the prefrontal cortex, …
Tauopathy Transcriptomes Tell Tantalizing Tales - ALZFORUM
Oct 18, 2023 · PSP and bvFTD are primary tauopathies, whereas in AD, tau pathology is secondary to Aβ. Though snRNA-Seq studies have blossomed in recent years, this is the first …
Single-cell multiregion dissection of Alzheimer’s disease
Jul 26, 2024 · Previously, the same group published an snRNA-Seq database of hundreds of cases from one brain region. In this study, they used snRNA-Seq to create a multiregion atlas …
Single-Nucleus RNA-Seq Is Not Suitable for Detection of
Oct 19, 2020 · Thrupp et al. propose that snRNA-Seq technology fails to recapitulate microglia activation states in humans because activation genes are underrepresented in non-diseased …
Single-cell genomic profiling of human dopamine neurons …
May 16, 2022 · The authors used advanced snRNA-sequencing and related methods on a special population of PD brain samples and normative control samples. They identified the …
‘Slide-tags’ Method Sharpens Spatial Transcriptomics - ALZFORUM
Dec 21, 2023 · As a proof-of-concept for spatial multiomic analysis, the researchers Slide-tagged a section of a metastatic melanoma sample, then used both snRNA- and ATAC-Seq to …
Tau, Speckle Wrecker, Disrupts the Nuclear Home - ALZFORUM
Apr 16, 2021 · They added that the field needs to uncover how tau aggregates mosey from the cytosol into the nucleus, and how the snRNA, snoRNA, or speckle proteins wind up in the …